Professor Laith Abu-Raddad (second left) and his team during a discussion.
DOHA: Researchers at Weill Cornell Medicine-Qatar (WCM-Q) found that transmission patterns of herpes simplex virus type 1 (HSV-1) are changing in Asia in a striking way, and that this virus is emerging as a key sexually transmitted infection.
According to findings published in the high impact and prestigious Journal of Clinical Infectious Diseases, 20 percent of genital herpes cases and six percent of genital ulcer cases are now caused by HSV-1.
HSV-1 is one of the most widespread infections globally. It is normally transmitted orally leading to blisters and lesions around the mouth known as oral herpes. Recent data from the United States and Western Europe, however, showed that HSV-1 can also be transmitted sexually leading to genital herpes and genital ulcer disease.
However, the study, conducted by the Infectious Disease Epidemiology Group (IDEG) at WCM-Q, demonstrated that this is also the case in Asia. The study found that although HSV-1 remains mostly orally transmitted, the virus is increasingly being transmitted sexually.
The study, which provided a comprehensive characterization of HSV-1 infection patterns in Asian countries, also estimated that about 50 percent of children are infected with the virus, all of whom are infected orally, and that 75 percent of adults are infected with the virus, through both the oral and genital routes.
“It was striking for us to discover this shift in HSV-1 transmission patterns from oral to genital infection in Asia,” said Manale Harfouche, joint first author of the study and senior research specialist at WCM-Q.
Laith Abu-Raddad, Principal investigator of the study and professor of healthcare policy and research at WCM-Q, concluded: “These findings demonstrate the criticality of accelerating HSV-1 vaccine development to control transmission and to prevent the medical and psychosocial disease burden that is emerging from this infection.”
